abstract：PURPOSE:Though type 2 diabetes mellitus (T2DM) is an important and independent risk factor for coronary artery disease (CAD) in the general population, the impact of T2DM on CAD in patients with familial hypercholesterolemia (FH) is less understood. Thus, the current study aimed to examine the features of FH patients w...

journal_title：Journal of endocrinological investigation

authors： Sun D,Cao YX,You XD,Zhou BY,Li S,Guo YL,Zhang Y,Wu NQ,Zhu CG,Gao Y,Dong QT,Liu G,Dong Q,Li JJ

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Insulinomas are a rare type of pancreatic neuroendocrine tumours characterized by insulin hypersecretion. They are considered malignant when metastases are present. Traditional therapies often promote only temporarily symptomatic relief and may be associated with severe adverse effects. There is scarce exp...

journal_title：Journal of endocrinological investigation

authors： Magalhães D,Sampaio IL,Ferreira G,Bogalho P,Martins-Branco D,Santos R,Duarte H

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:We recently demonstrated a protective effect of the farnesoid X receptor agonist obeticholic acid (OCA) in rat models of bleomycin-induced pulmonary fibrosis (PF). Aim of the present study was to investigate whether the positive effects of OCA treatment are apparent also on ongoing bleomycin-induced PF, i.e., a...

journal_title：Journal of endocrinological investigation

authors： Comeglio P,Filippi S,Sarchielli E,Morelli A,Cellai I,Corno C,Pini A,Adorini L,Vannelli GB,Maggi M,Vignozzi L

更新日期：2019-03-01 00:00:00

abstract：:Unfortunately, the author name and his affiliation were published in the original publication. They have now been removed. ...

journal_title：Journal of endocrinological investigation

authors：

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role ...

journal_title：Journal of endocrinological investigation

authors： Demirpence M,Guler A,Yilmaz H,Sayin A,Pekcevik Y,Turkon H,Colak A,Ari EM,Aslanipour B,Kocabas GU,Calan M

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Testosterone deficiency might be associated with vitamin D levels in hypogonadal men, but it is not clear whether testosterone can affect vitamin D and fibroblast growth factor-23 (FGF23), either directly or indirectly via aromatization to estradiol. We aimed to investigate the role of testosterone on vitami...

journal_title：Journal of endocrinological investigation

authors： Saki F,Kasaee SR,Sadeghian F,Koohpeyma F,Omrani GHR

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:The diagnosis of polycystic ovary syndrome (PCOS) is based on a combination of various clinical phenotypes in each patient. However, insulin resistance (IR) and dysmetabolism are not included in the diagnostic criteria of PCOS. Therefore, the definition of PCOS is controversial. The objective of this study is t...

journal_title：Journal of endocrinological investigation

authors： Zhang L,Fang X,Li L,Liu R,Zhang C,Liu H,Tan M,Yang G

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:The review focused on the role that media reporting plays in the level of public awareness about osteoporosis and its influence on osteoporosis treatment decisions. METHODS:We reviewed the literature on the role of media on three main aspects influencing patient adherence to osteoporosis treatment: the awarene...

journal_title：Journal of endocrinological investigation

authors： Cipriani C,Pepe J,Minisola S,Lewiecki EM

更新日期：2018-12-01 00:00:00

abstract：: ...

journal_title：Journal of endocrinological investigation

authors： Lazzeri D,Al-Mousawi A,Nicoli F

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Antithyroid drugs (ATDs) are first-line treatment for Graves' hyperthyroidism worldwide, but relapses are frequent. The reliability of individual risk factors to predict at baseline subsequent relapse is poor. Predictive scores grouping single risk factors might help to select the best treatment (pharmacolog...

journal_title：Journal of endocrinological investigation

authors： Masiello E,Veronesi G,Gallo D,Premoli P,Bianconi E,Rosetti S,Cusini C,Sabatino J,Ippolito S,Piantanida E,Tanda ML,Chiovato L,Wiersinga WM,Bartalena L

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:This study was aimed at assessing the incidence and timing of thyroid nodules recurrence, defined as appearance of new benign or malignant nodules in contralateral lobe in patients with benign thyroid nodules or thyroid microcarcinoma treated with lobo-isthmectomy. Patient's characteristics and risk factors ass...

journal_title：Journal of endocrinological investigation

authors： Zatelli MC,Lamartina L,Meringolo D,Arvat E,Damiani L,Grani G,Nervo A,Durante C,Giacomelli L

更新日期：2018-12-01 00:00:00

abstract：:Metabolic diseases are associated with chronic low-grade inflammation, which has been indicated as a potential mediator of endothelial dysfunction and cardiovascular disease. Visceral adiposity is thought to be the starting condition of the inflammatory state through the release of inflammatory cytokines, including TN...

journal_title：Journal of endocrinological investigation

authors： Maiorino MI,Bellastella G,Giugliano D,Esposito K

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the possible association of insulin-like growth factor-1 (IGF-1) with the pathogenesis of non-functioning adrenocortical adenomas (NFAs). METHODS:This study included 50 female patients (mean age 54 years) with NFAs, 55 patients (mean age 48 years; 20 male, 35 female) wi...

journal_title：Journal of endocrinological investigation

authors： Bahadir CT,Ecemis GC,Atmaca H

更新日期：2018-11-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO), also known as "oncogenic osteomalacia", is a rare cause of osteomalacia. TIO often has an insidious onset characterized clinically by progressive muscle weakness and bone pain with fractures. The hallmark biochemical finding is a persistent low serum phosphorus concentration due to re...

journal_title：Journal of endocrinological investigation

authors： Boland JM,Tebben PJ,Folpe AL

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Although vitamin D is reportedly associated with various cancers, the association between vitamin D and thyroid cancer is indefinite. We aimed to investigate whether this association applies to thyroid cancer (TC). METHODS:A total of 276 Chinese Han people were recruited in a current matched case-control study...

journal_title：Journal of endocrinological investigation

authors： Hu MJ,Zhang Q,Liang L,Wang SY,Zheng XC,Zhou MM,Yang YW,Zhong Q,Huang F

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Few examples of the involvement of a single gene in idiopathic short stature have been described until now. Our aim was to identify the causative gene of proportionate short stature in a large family showing co-segregation of the phenotype with the reciprocal translocation t(10;15)(q22;q24). METHODS:FISH mappi...

journal_title：Journal of endocrinological investigation

authors： Crippa M,Giangiobbe S,Villa R,Bestetti I,De Filippis T,Fatti L,Taurino J,Larizza L,Persani L,Bellini F,Finelli P,Bonati MT

更新日期：2018-08-01 00:00:00

abstract：:Unfortunately, the fourth author's middle name was missed out in the original publication of this article. The complete correct name should read as follows. ...

journal_title：Journal of endocrinological investigation

authors： Tresoldi AS,Sburlati LF,Rodari M,Schinkelshoek MS,Perrino M,De Leo S,Montefusco L,Colombo P,Arosio M,Lania AGA,Fugazzola L,Chiti A

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:Arginine vasopressin (AVP) may be involved in metabolic syndrome (MetS) by altering liver glycogenolysis, insulin and glucagon secretion, and pituitary ACTH release. Moreover, AVP stimulates the expression of 11β-hydroxysteroid-dehydrogenase-type 2 (11β-HSD2) in mineralocorticosteroid cells. We explored whether...

journal_title：Journal of endocrinological investigation

authors： Canivell S,Mohaupt M,Ackermann D,Pruijm M,Guessous I,Ehret G,Escher G,Pechère-Bertschi A,Vogt B,Devuyst O,Burnier M,Martin PY,Ponte B,Bochud M

更新日期：2018-07-01 00:00:00

abstract：PURPOSE:To report the clinical implications of an initial experience with transoral endoscopic thyroidectomy vestibular approach (TOETVA). METHODS:From March to November 2017, five cases of TOETVA were performed. Data reported include patient demographics, indication for surgery, extent of surgery, operative time, the...

journal_title：Journal of endocrinological investigation

authors： Bakkar S,Al Hyari M,Naghawi M,Corsini C,Miccoli P

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Graves' orbitopathy (GO) is an inflammatory orbital disease of autoimmune origin with the potential to cause severe functional and psychosocial effects. The pathogenesis has not been fully elucidated. We investigated whether DNA methylation was associated with GO incidence in Chinese patients. MATERIALS AND ...

journal_title：Journal of endocrinological investigation

authors： Xin Z,Hua L,Shi TT,Tuo X,Yang FY,Li Y,Cao X,Yang JK

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Aims of this study were to evaluate the agreement between the short and long versions of the International Physical Activity Questionnaire (IPAQ: Italian versions), their reproducibility (agreement and reliability) and construct validity (relative to pedometry) in a clinical population. METHODS:Ninety patients...

journal_title：Journal of endocrinological investigation

authors： Minetto MA,Motta G,Gorji NE,Lucini D,Biolo G,Pigozzi F,Portincasa P,Maffiuletti NA

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Elimination of thyroid antigens by total thyroid ablation (TTA), namely, thyroidectomy followed by radioiodine, may be beneficial for Graves' Orbitopathy (GO). TTA is usually performed with a 131I dose of 30 mCi. In Italy, this dose must be followed by a 24-h protected hospitalization, with increase in the wa...

journal_title：Journal of endocrinological investigation

authors： Leo M,Sabini E,Ionni I,Sframeli A,Mazzi B,Menconi F,Molinaro E,Bianchi F,Brozzi F,Santini P,Elisei R,Nardi M,Vitti P,Marcocci C,Marinò M

更新日期：2018-03-01 00:00:00

abstract：:The occurrence of a genetic background in the etiology of polycystic ovarian syndrome (PCOS) represents the rational basis to postulate the existence of a male PCOS equivalent. Hormonal and metabolic abnormalities have been described in male relatives of women with PCOS. These males also have a higher prevalence of ea...

journal_title：Journal of endocrinological investigation

authors： Cannarella R,Condorelli RA,Mongioì LM,La Vignera S,Calogero AE

更新日期：2018-01-01 00:00:00

abstract：:The pathogenesis of human obesity is the result of dysregulation of the reciprocal relationship between food intake and energy expenditure (EE), which influences daily energy balance and ultimately leads to weight gain. According to principles of energy homeostasis, a relatively lower EE in a setting of energy balance...

journal_title：Journal of endocrinological investigation

authors： Piaggi P,Vinales KL,Basolo A,Santini F,Krakoff J

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The Arnolfini portrait painted by Jan van Eyck in 1434 remains one of the most puzzling yet alluring paintings of prerenaissance western art. PURPOSE:The painting is renowned for its exactitude in brush strokes, textures and the distinctive morphology of the main character Arnolfini. The nature of these req...

journal_title：Journal of endocrinological investigation

authors： Ashrafian H

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Persistence is commonly considered a key factor for the successful management of osteoporosis and fragility fractures. Denosumab is the first biologic agent developed for the treatment of osteoporosis with satisfying data regarding the persistence with this therapy. AIM:The purpose of this multicenter obser...

journal_title：Journal of endocrinological investigation

authors： Migliaccio S,Francomano D,Romagnoli E,Marocco C,Fornari R,Resmini G,Buffa A,Di Pietro G,Corvaglia S,Gimigliano F,Moretti A,de Sire A,Malavolta N,Lenzi A,Greco EA,Iolascon G

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Subcutaneous insulin absorption is one of the key factors affecting glycemic control in patients with diabetes mellitus under insulin therapy. Insulin-induced subcutaneous lipohypertrophy has been reported to impair insulin regular absorption and hence glycemic control. So far, lipohypertrophy diagnosis has o...

journal_title：Journal of endocrinological investigation

authors： Bertuzzi F,Meneghini E,Bruschi E,Luzi L,Nichelatti M,Epis O

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:This study aimed to investigate the interactive effect of polycystic ovary syndrome (PCOS) status and obesity status on the serum levels of adipokines. METHODS:In this comparative case-control cross-sectional study, 58 women with PCOS and 104 eumenorrheic non-hirsute women as the control group were recruited. ...

journal_title：Journal of endocrinological investigation

authors： Behboudi-Gandevani S,Ramezani Tehrani F,Bidhendi Yarandi R,Noroozzadeh M,Hedayati M,Azizi F

更新日期：2017-08-01 00:00:00

abstract：:Puberty is a major developmental stage. Damaging mutations, considered as "mistakes of nature", have contributed to the unraveling of the networks implicated in the normal initiation of puberty. Genes involved in the abnormal hypothalamic-pituitary-gonadal (HPG) axis development, in the normosmic idiopathic hypogonado...

journal_title：Journal of endocrinological investigation

authors： Leka-Emiri S,Chrousos GP,Kanaka-Gantenbein C

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope®, a somatropin biosimilar to Genotropin®, in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults study. METHODS:The PATRO Adults study is an ongoing observational, longitudinal, non...

journal_title：Journal of endocrinological investigation

authors： Ferone D,Profka E,Gasco V,Ambrosio MR,Colao A,Di Somma C,Puxeddu E,Arnaldi G,Pagano C,Zecchi E,Pietropoli A,Beck-Peccoz P

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Remission of acromegaly has been reported after somatostatin analogs withdrawal, but not after withdrawal of combination therapy with cabergoline, and only in case reports of patients controlled by cabergoline alone. METHODS:To establish the remission rates (normal IGF-1 for age/sex: IGF-1 ≤ 1.00 xULN) after w...

journal_title：Journal of endocrinological investigation

authors： Casagrande A,Bronstein MD,Jallad RS,Mota JI,Tabet A,Abucham J

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow...

journal_title：Journal of endocrinological investigation

authors： Bartalena L,Veronesi G,Krassas GE,Wiersinga WM,Marcocci C,Marinò M,Salvi M,Daumerie C,Bournaud C,Stahl M,Sassi L,Azzolini C,Boboridis KG,Mourits MP,Soeters MR,Baldeschi L,Nardi M,Currò N,Boschi A,Bernard M,von Arx

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of testosterone treatment on biomarkers calprotectin, fibroblast growth factor 23 (FGF23), soluble Klotho, phosphate, calcium, parathyroid hormone, creatinine and estimated glomerular filtration rate. DESIGN:Randomized, double-blinded, placebo-controlled study. SETTING:Odense Andr...

journal_title：Journal of endocrinological investigation

authors： Pedersen L,Christensen LL,Pedersen SM,Andersen M

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:Polycystic ovary syndrome (PCOS) was associated with a number of polymorphisms of genes involved in insulin signaling. So far, they have been studied separately. The aim of this study was to verify the impact of the coexistence of two polymorphisms of insulin signaling. METHODS:One hundred consecutive PCOS wom...

journal_title：Journal of endocrinological investigation

authors： Pappalardo MA,Vita R,Di Bari F,Le Donne M,Trimarchi F,Benvenga S

更新日期：2017-04-01 00:00:00

abstract：PURPOSE:To determine the incidence and determinants of developing abnormalities on the 12-lead electrocardiogram (ECG) in persons with type 1 diabetes. METHODS:We evaluated the distribution of ECG abnormalities and risk factors for developing new abnormalities in 266 (mean age = 44 years ± 9.0; 50 % female) people wit...

journal_title：Journal of endocrinological investigation

authors： O'Neal WT,Lee KE,Soliman EZ,Klein R,Klein BE

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing effects. Accumulating data implied that vaspin represents a compensatory mechanism but it is unknown how vaspin change during ageing. This study was designed to examine the correlation between plasma ...

journal_title：Journal of endocrinological investigation

authors： Xu X,Wen J,Lu Y,Ji H,Zhuang J,Su Y,Liu B,Li H,Xu Y

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the prevalence and risk factors associated with female sexual dysfunction (FSD) in young women with type 1 diabetes treated with different intensive insulin regimens. METHODS:Type 1 diabetic women aged 18-35 years were included in this study if they had stable couple relat...

journal_title：Journal of endocrinological investigation

authors： Maiorino MI,Bellastella G,Castaldo F,Petrizzo M,Giugliano D,Esposito K

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:The Merseburg triad (hyperthyroidism, goiter, and orbitopathy) characterizes classical description of Graves' disease (GD). Aim of this observational, longitudinal study was to evaluate the current clinical features of newly diagnosed GD in Italy. MATERIALS AND METHODS:In two Northern Italy centers (Varese a...

journal_title：Journal of endocrinological investigation

authors： Bartalena L,Masiello E,Magri F,Veronesi G,Bianconi E,Zerbini F,Gaiti M,Spreafico E,Gallo D,Premoli P,Piantanida E,Tanda ML,Ferrario M,Vitti P,Chiovato L

更新日期：2016-12-01 00:00:00

abstract：:Graves' disease (GD) is the most prevalent cause of thyrotoxicosis in children. Because spontaneous and lasting resolution of this condition occurs in only a minority of patients, most pediatric patients with GD will need radioactive iodine treatment (131I) or thyroidectomy. Whereas the medication propylthiouracil (PT...

journal_title：Journal of endocrinological investigation

authors： Rivkees SA

更新日期：2016-11-01 00:00:00

abstract：PURPOSE:Nonalcoholic fatty liver disease (NAFLD) is associated with various metabolic abnormalities that can increase the risk of an osteoporotic fracture. Across the few previous studies of the association between NAFLD and bone mineral density (BMD), the association was not consistent. We examined the association bet...

journal_title：Journal of endocrinological investigation

authors： Lee SH,Yun JM,Kim SH,Seo YG,Min H,Chung E,Bae YS,Ryou IS,Cho B

更新日期：2016-11-01 00:00:00